INTERLEUKIN-8 SYNTHESIS AND THE ONSET OF LABOR

被引：207
|
作者：
OSMERS, RGW [1 ]
BLASER, J [1 ]
KUHN, W [1 ]
TSCHESCHE, H [1 ]
机构：
[1] UNIV BIELEFELD,DEPT BIOCHEM,W-4800 BIELEFELD,GERMANY
来源：
OBSTETRICS AND GYNECOLOGY | 1995年 / 86卷 / 02期
关键词：
D O I：
10.1016/0029-7844(95)93704-4
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To examine the role of cytokines in cervical dilation. Methods: In 55 patients undergoing cesarean delivery, we took samples from the lower uterine segment, the decidua, and the membranes. We determined the concentrations of interleukin (IL)-2, IL-8, tumor necrosis factor-alpha, matrix metalloproteinase (MMP)-8, and MMP-9 in the different tissues. Results: Depending on the state of labor, we observed a significant increase (P < .001) in IL-8 concentrations in the lower uterine segment. The leukocyte enzymes MMP-8 and MMP-9 were highly significantly correlated with the IL-8 concentrations. Conclusion: Interleukin-8 is critically involved in the process of parturition in humans. Interleukin-6 concentrations in the myometrium, decidua, and membranes correlated strongly with the observed MMP-8 and MMP-9 concentrations.
引用
收藏
页码：223 / 229
页数：7
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