NORMAL FOOD-INTAKE AND GROWTH IN HYPERPROLACTINEMIC RATS

被引:7
|
作者
ADLER, RA
KRIEG, RJ
机构
[1] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT INTERNAL MED,RICHMOND,VA 23298
[2] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT ANAT,RICHMOND,VA 23298
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1991年 / 261卷 / 03期
关键词
PROLACTIN; LACTATION; GROWTH HORMONE; ANTERIOR PITUITARY GRAFTS;
D O I
10.1152/ajpregu.1991.261.3.R548
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Normal lactation, a state of chronic hyperprolactinemia, is often accompanied by increased food intake. Two recent reports suggested that, in rats, prolactin (PRL) administration or chronic endogenous PRL excess led to increased food intake and growth. Similar methods of achieving augmented circulating levels of PRL in rats have been employed in our laboratory. Rats with extra anterior pituitary (AP) grafts under the kidney capsule have chronically elevated circulating PRL levels. However, in several experiments, weight gain, food intake, and fecal weight were the same in AP-grafted rats and in control muscle-grafted rats. In addition, the AP-grafted rat model was modified to demonstrate that PRL-induced increases in adrenal glucocorticoids and decreases in estrogens did not provoke alterations in eating behavior. Injection of homologous PRL for 8 days did not increase weight gain in normal or hypophysectomized rats. These data suggest that neither the chronic PRL excess caused by AP grafts nor the acute PRL excess caused by rat PRL injections increases food intake or weight gain.
引用
收藏
页码:R548 / R552
页数:5
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