PROLACTIN RESPONSE TO DL-FENFLURAMINE IN PANIC DISORDER

被引：23
|
作者：
APOSTOLOPOULOS, M [1 ]
JUDD, FK [1 ]
BURROWS, GD [1 ]
NORMAN, TR [1 ]
机构：
[1] UNIV MELBOURNE,AUSTIN HOSP,DEPT PSYCHIAT,HEIDELBERG,VIC 3084,AUSTRALIA
来源：
PSYCHONEUROENDOCRINOLOGY | 1993年 / 18卷 / 5-6期
关键词：
D O I：
10.1016/0306-4530(93)90009-A
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The objective of this study was to test the hypothesis that serotonin receptors are hypersensitive in patients with panic disorder. Eleven patients and 12 controls received a single PO dose of 60 mg of dl-fenfluramine at 0900h on a single occasion. Blood samples were collected with an indwelling intravenous catheter at 30-min intervals from 0930h to 1530h and prolactin determined by radioimmunoassay. In both groups, fenfluramine induced a rise in the plasma prolactin concentration from baseline. The patients showed a greater increase in prolactin response than the normal controls. This result is consistent with the hypothesis of increased serotonin receptor function in patients with panic disorder.
引用
收藏
页码：337 / 342
页数：6
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