TRANSACTIVATION AND DNA-BINDING PROPERTIES OF THE TRANSCRIPTION FACTOR, SOX-18

被引：75

作者：

HOSKING, BM ^{[1
]}

MUSCAT, GEO ^{[1
]}

KOOPMAN, PA ^{[1
]}

DOWHAN, DH ^{[1
]}

DUNN, TL ^{[1
]}

机构：

[1] UNIV QUEENSLAND,CTR MOLEC & CELLULAR BIOL,ST LUCIA,QLD 4072,AUSTRALIA

来源：

NUCLEIC ACIDS RESEARCH | 1995年 / 23卷 / 14期

关键词：

D O I：

10.1093/nar/23.14.2626

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sox-18 is a member of the Sox multi-gene family (Sry-related HMG-box gene), We have bacterially expressed this 378 amino acid protein and demonstrated sequence-specific binding to the Sox DNA-binding motif AACAAAG. A distinct 95 amino acid activation domain was mapped in Sox-18 using GAL4-Sox-18 fusions (amino acids 160-225). Furthermore, Sox-18 was capable of trans-activating gene expression through the AACAAAG motif. Our results suggest that Sox-18 functions as a classical trans-activator of gene expression.

引用

页码：2626 / 2628

页数：3

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