Five percent to ten percent of all live births are premature. Modern neonatology has dramatically improved survival rates. Morbidity rates, however, are as high as 60%, according to some studies. In this paper, outcome and intervention findings are described. Experimental, familial and socioeconomic factors interact synergistically with preterm birth and biological vulnerability to create cognitive, behavioural and interpersonal disorders. Principles of intervention are suggested, based on promoting organization within the infant and a responsive, active approach in the caregivers.