AUTOPSY DIAGNOSES OF ALZHEIMER-DISEASE - INDEPENDENT REVIEWS AND CLINICAL IMPLICATIONS

被引:4
|
作者
JARVIK, LF
MATSUYAMA, SS
CHUI, H
SCHEIBEL, AB
VINTERS, HV
机构
[1] VET ADM MED CTR BRENTWOOD, PSYCHOGERIATR UNIT & LAB, LOS ANGELES, CA 90073 USA
[2] UNIV CALIF LOS ANGELES, NEUROPSYCHIAT INST & HOSP, DEPT PSYCHIAT & BIOBEHAV SCI, LOS ANGELES, CA 90024 USA
[3] UNIV SO CALIF, SCH MED, DEPT NEUROL, LOS ANGELES, CA 90033 USA
[4] UNIV SO CALIF, RANCHO LOS AMIGOS HOSP, DOWNEY, CA 90242 USA
[5] UNIV CALIF LOS ANGELES, INST BRAIN RES, LOS ANGELES, CA 90024 USA
[6] UNIV CALIF LOS ANGELES, DEPT ANAT, LOS ANGELES, CA 90024 USA
[7] UNIV CALIF LOS ANGELES, DEPT PATHOL & LAB MED, LOS ANGELES, CA 90024 USA
关键词
AUTOPSY; ALZHEIMER DISEASE; DEMENTIA; NEUROPATHOLOGY;
D O I
10.1002/gps.930100610
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
At present, the neuropathologic examination is universally regarded as essential for the final diagnosis of Alzheimer disease (AD). However, there is absence of agreement on what areas to examine, what stains to use, which lesions to report, and how to interpret other neuropathologic findings. In this study, we describe the results of reviewing the neuropathologic findings in probands from a family study of AD who had received a clinical diagnosis of 'probable AD' (N = 33). A neuropathologic diagnosis of AD was received for 88% of the probands, a proportion entirely in agreement with that reported in the literature. An independent review of the autopsy reports found variability in whether the neuropathologic diagnosis was based on the presence of plaques or tangles or both. Further, when a subset of histologic slides was reviewed by two researchers working in the field of AD, there were substantial diagnostic discrepancies. These findings indicate the need for standardized protocols, but suggest that even they have limitations. These limitations are of particular concern when estimating vulnerability to AD of first-degree relatives. Thus, while neuropathologic examination continues to provide invaluable information about the causes of dementia, it cannot be regarded as a gold standard for diagnosis of individual cases.
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页码:505 / 510
页数:6
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