5-HYDROXYTRYPTAMINE (5-HT) AND THE INITIATION OF MIGRAINE - NEW PERSPECTIVES

被引：0
|
作者：
FOZARD, JR
KALKMAN, HO
机构：
来源：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 1994年 / 350卷 / 03期
关键词：
MIGRAINE; NITRIC OXIDE; ENDOTHELIUM; 5-HT(2C) RECEPTORS; 5-HT(2B) RECEPTORS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The hypothesis that 5-hydroxytryptamine (5-HT) acting through 5-HTHC receptors is a key factor in the initiation of migraine has been re-evaluated in the light of recent basic and clinical scientific developments. The key findings are that nitric oxide is an important trigger for migraine, that 5-HT2B/5-HT2C receptors are present on endothelial cells and trigger nitric oxide release when activated and that supersensitivity of the 5-HT2B/ 5-HT2C receptor is a neurochemical feature predisposing to headache. Taken together the data bring new perspectives to the role of 5-HT acting through 5-HT2C (or closely similar) receptors in the initiation of migraine.
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页码：225 / 229
页数：5
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