Effect of DNA Methylation in Various Diseases and the Probable Protective Role of Nutrition: A Mini-Review

被引：37
|
作者：
Kandi, Venkataramana [1 ]
Vadakedath, Sabitha [2 ]
机构：
[1] Prathima Inst Med Sci, Dept Microbiol, Nagunur, India
[2] Chalmeda Anand Rao Inst Med Sci, Biochem, Karimnagar, India
来源：
CUREUS | 2015年 / 7卷 / 08期
关键词：
dna methylation; epigenetic modifications; imprinting disorders; methyltransferase;
D O I：
10.7759/cureus.309
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
DNA methylation, a process of adding a methyl group to DNA done by a DNA methyltransferase is a heritable (epigenetic) alteration leading to cancer, atherosclerosis, nervous disorders (Imprinting disorders), and cardiovascular diseases. The role of nutrition in DNA methylation is revealed by identification of methyl variable positions (MVP) on DNA. These regions are more susceptible to DNA methylations. Nutritional supplementation of folic acid and methionine in utero and in adults decreased epigenetic modifications due to its role in DNA metabolism (one carbon metabolism). Thus, in utero and adult supplementation of folic acid and methionine may reduce DNA methylation. This review attempts to highlight the process of DNA methylation, its effect on various diseases, and the probable protective role of nutrition.
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页数：6
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