Health Related Quality of Life, Depression, Anxiety and Stress in Patients with Beta-Thalassemia Major

Background Awareness of factors associated with quality of life (QOL) in patients with betaThalassemia major (beta-TM) is necessary to develop clinical programs in order to improve social support and QOL in P-TM patients. This study aimed to examine QoL, depression, anxiety, and stress in beta-TM patients in Ahvaz, Iran. Materials and Methods A cross-sectional study was conducted on173 beta-TM patients aged >= 12 years (12-18=55, >= 19=118). Subjects were selected using a census method. Data collection instrument consisted of three parts including: demographic questions, SF-36 questionnaire and depression, anxiety, and stress scale (DAS-21). Results The participants obtained a mean score of 64.38 +/- 18.20 for QOL, 6.4 +/- 5.1 for depression, 4.8 +/- 3.9 for anxiety, and 7.3 +/- 4.9 for stress. Significant relationship was found between QOL and employment (P=0.02) and education level (P<0.001). Patients in the age group of 12-18 years old had higher mean scores in the majority of QoL dimensions than those aged19. The mean scores of depression, anxiety, and stress were higher in patients aged <= 19. No significant correlation was observed between QOL and depression, anxiety, stress scores, and other demographic variables. Moreover, a significant inverse correlation was found between QOL and depression (P<0.001,r=-0.62), anxiety (P<0.001,r=-0.55), and stress scores (P<0.001, r=-0.5). Conclusion This study showed that beta-TM patients experienced a considerable decrease both in their overall QoL and in its dimensions. A majority of the beta-TM patients were also suffered from mild to severe depression, anxiety, and stress.