SYNTHESIS AND ABSOLUTE-CONFIGURATION OF (-)-STYPOLDIONE

被引：21
|
作者：
MORI, K
KOGA, Y
机构：
[1] Department of Agricultural Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo, 113
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 05期
关键词：
D O I：
10.1016/S0960-894X(00)80153-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
(S)-3-Hydroxy-2,2-dimethylcyclohexanone (4) was converted into (-)-stypoldione (1), the ichthyotoxic and cytotoxic metabolite of the brown alga, Stypopodium zonale (Lamouroux) Papenfus. The present synthesis established the absolute configuration of (-)-stypoldione as depicted in (1).
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页码：391 / 394
页数：4
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