THE STRUCTURE OF THE HOMEODOMAIN AND ITS FUNCTIONAL IMPLICATIONS

被引：223
|
作者：
GEHRING, WJ [1 ]
MULLER, M [1 ]
AFFOLTER, M [1 ]
PERCIVALSMITH, A [1 ]
BILLETER, M [1 ]
QIAN, YQ [1 ]
OTTING, G [1 ]
WUTHRICH, K [1 ]
机构：
[1] SWISS FED INST TECHNOL,INST MOLEK BIOL & BIOPHYS,CH-8093 ZURICH,SWITZERLAND
来源：
TRENDS IN GENETICS | 1990年 / 6卷 / 10期
关键词：
D O I：
10.1016/0168-9525(90)90253-3
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution. © 1990.
引用
收藏
页码：323 / 329
页数：7
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