EFFECTS OF AGING ON MICROGLIA IN THE NORMAL RAT-BRAIN - IMMUNOHISTOCHEMICAL OBSERVATIONS

被引：143
|
作者：
OGURA, K [1 ]
OGAWA, M [1 ]
YOSHIDA, M [1 ]
机构：
[1] JICHI MED SCH,DEPT NEUROL,MINAMI KAWACHI,TOCHIGI 32904,JAPAN
来源：
NEUROREPORT | 1994年 / 5卷 / 10期
关键词：
MACROPHAGE; MICROGLIA; RAT; BRAIN; AGING;
D O I：
10.1097/00001756-199406020-00016
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
THE numbers of ramified microglia stained by mouse monoclonal antibodies (OX-6 and X-42) in various regions of the brain were compared in the young (8 weeks) and aged (12 months) rats. OX-6-positive microglia increased in number with ageing, but OX-42-positive microglia did not. In both young and aged rats, the number of OX-6-positive microglia in white matter was higher than that in grey matter, but the number of OX-42-positive microglia in white matter was the same as that in grey matter. OX-42 stains microglia in both activated and resting states, whereas OX-6 stains mainly microglia in the activated state. Our findings suggest that microglia become activated with age-related changes, especially in white matter.
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页码：1224 / 1226
页数：3
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