Microwave-assisted synthesis of 5,10,15,20-tetrakis(4-nitrophenyl)porphyrin and zinc derivative and study of their bacterial photoinactivation

被引：0
|
作者：
Rahimi, Rahmatollah [1 ]
Fayyaz, Fatemeh [1 ]
Rassa, Mehdi [2 ]
Rabbani, Mahboubeh [1 ]
机构：
[1] Iran Univ Sci & Technol, Dept Chem, Bioinorgan Chem Lab, Tehran 1684613114, Iran
[2] Univ Guilan, Fac Sci, Dept Biol, Rasht, Iran
来源：
IRANIAN CHEMICAL COMMUNICATION | 2016年 / 4卷 / 02期
关键词：
Antimicrobial activity; Bacillus subtilis; Photoinactivation; Pseudomonas aeruginosa; TNPP;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this study, 5,10,15,20-tetrakis(4-nitrophenyl)porphyrin (TNPP) and its zinc porphyrin complex (ZnTNPP) were synthesized in situ using the microwave method and identified by UV-Vis, FT-IR and H-1 NMR. The photostability and photodynamic antimicrobial activity (PACT) of these compounds were investigated on Pseudomonas aeruginosa and Bacillus subtilis under visible light irradiation. MIC, MBC and inhibition zones produced by these compounds were determined and the number of bacteria counted. The results indicated that both compounds have significant stability when illuminated for various illumination periods in nutrient broth media. Both compounds exhibited more effective activity against P. aeruginosa than B. subtilis in nutrient agar.
引用
收藏
页码：175 / 185
页数：11
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