QUANTITATIVE-ANALYSIS OF MYELIN PROTEIN GENE-EXPRESSION DURING DEVELOPMENT IN THE RAT SCIATIC-NERVE

被引:89
|
作者
STAHL, N
HARRY, J
POPKO, B
机构
[1] UNIV N CAROLINA, BIOL SCI RES CTR, CB 7250, CHAPEL HILL, NC 27599 USA
[2] UNIV N CAROLINA, DEPT BIOCHEM, CHAPEL HILL, NC 27599 USA
[3] UNIV N CAROLINA, PROGRAM MOLEC BIOL & BIOTECHNOL, CHAPEL HILL, NC 27599 USA
来源
MOLECULAR BRAIN RESEARCH | 1990年 / 8卷 / 03期
关键词
Development; mRNA quantitation; Myelin protein gene expression; Schwann cell;
D O I
10.1016/0169-328X(90)90018-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We determined the temporal profile of expression of the genes encoding the P0 glycoprotein, the myelin-associated glycoprotein (MAG), the myelin basic protein (MBP), the proteolipid protein (PLP), and 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP) in the sciatic nerve of rats. The level of expression of the MAG gene occurred maximally in animals 13 days of age, approximately one week earlier than the peak expression of the MBP and P0 genes. The genes encoding PLP and CNP were not expressed developmentally in a manner that correlated with the myelination of the sciatic nerve. Furthermore, using RNA synthesized in vitro, specific for each of the myelin protein genes, we have determined the absolute amounts of messenger RNA for the various myelin proteins in total RNA from sciatic nerves. P0 and MBP RNA were present at very high levels, whereas the amount of MAG, PLP and CNP RNA were much less. © 1990.
引用
收藏
页码:209 / 212
页数:4
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