CONTRACTILE RESPONSE OF GUINEA-PIG ILEUM BY REPETITIVE APPLICATION OF MORPHINE

被引：2
|
作者：
KUSAMA, T [1 ]
MURAKOSHI, Y [1 ]
MURAKAMI, H [1 ]
机构：
[1] NIHON UNIV,COLL PHARM,DEPT PHARMACOL,FUNABASHI,CHIBA 274,JAPAN
来源：
GENERAL PHARMACOLOGY | 1992年 / 23卷 / 03期
关键词：
D O I：
10.1016/0306-3623(92)90100-X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. The repetitive application of morphine gradually induced a contracture in the isolated guinea pig ileum. 2. The optimum conditions for induction of the contracture were as follows: the concentration, incubation time and washout time of morphine were 1 or 10-mu-M, 2 and 3 min, respectively. 3. Preincubation with naloxone or TTX blocked this morphine-induced contracture. 4. Among twitch-inhibiting drugs, only clonidine induced a contracture similar to that induced by morphine, while tetrodotoxin (TTX) and adenosine did not. 5. The contracture was also observed in the longitudinal muscle-myenteric plexus preparations. 6. These findings indicate that morphine has a dual inhibitory and excitatory action on the guinea pig ileum and that its repetitive application preferentially diminish the inhibitory one.
引用
收藏
页码：391 / 396
页数：6
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