Levonorgestril Intrauterine System (LNG-IUS) Versus Medroxyprogesterone Acetate for the Treatment of Endometrial Hyperplasia: A Randomized Control Trial

Aim: To compare the effectiveness of Levonorgestrel Intrauterine Device with Injectable Medroxyprogesterone in treating Endometrial Hyperplasia. Study Design: Randomized Control Trial Settings: Obstetrics & Gynecology Department, Lady Willingdon Hospital, Lahore. Duration of the study: Six months, from 09-08-2016 to 08-02-2017. Sample size: A total of 140 subjects taken by non-probability consecutive sampling technique, were divided into group A&B by lottery, with 70 patients in each group. Selection Criteria: Women > 35 years, diagnosed with endometrial hyperplasia (endometrial. thickness>7mm on transvaginal ultrasound and were confirmed on histopathology of endometrial specimen obtained by D&N Data analysis: Collected information was entered in SPSS Version 21and results obtained. Results: Average age of patients was 55.91 +/- 11.16 years. The mean duration of diagnosis of EH was 2.94 +/- 1.42 months. The effectiveness achieved in 121(86.43%) patients. After the statistical analysis, the groups under study showed significant difference i.e. p-value=0.026. Conclusion: It has been proved in our study that the LNG-IUD is significantly more effective and reliable as compared to Inj. Medroxyprogesterone in the management of EH.