NEW SPECTROSCOPIC TOOL - ABSOLUTE-CONFIGURATION DETERMINATION OF PHARMACEUTICAL COMPOUNDS BY VIBRATIONAL CIRCULAR-DICHROISM

The enantiomers of numerous new chiral substances can only be separated by chiral chromatographic techniques. In such cases, the absolute configurations may not be known a priori, and chiroptical spectroscopic techniques are useful in deriving that information. The utility of vibrational circular dichroism (VCD) in determining the conformational and configurational information is illustrated here using the recently developed experimental and interpretational methods for pharmaceutical compounds used for inducing anesthesia.