V(D)J RECOMBINATION GETS A BREAK

被引：38
|
作者：
GELLERT, M
机构：
来源：
TRENDS IN GENETICS | 1992年 / 8卷 / 12期
关键词：
D O I：
10.1016/0168-9525(92)90322-U
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The diversity of immunoglobulins and T cell receptors is largely due to the assembly of functional genes from separate segments. The mechanism by which these gene fragments are joined is starting to be deciphered, with broken DNA molecules that may be intermediates in the reaction providing a new clue.
引用
收藏
页码：408 / 412
页数：5
相关论文
共 50 条
  • [1] A NEW BREAK IN V(D)J RECOMBINATION
    FERGUSON, SE
    THOMPSON, CB
    CURRENT BIOLOGY, 1993, 3 (01) : 51 - 53
  • [2] V(D)J recombination
    Schatz, DG
    IMMUNOLOGICAL REVIEWS, 2004, 200 : 5 - 11
  • [3] V(D)J recombination
    Sekiguchi, J
    Frank, K
    CURRENT BIOLOGY, 1999, 9 (22) : R835 - R835
  • [4] IMPAIRMENT OF V(D)J RECOMBINATION IN DOUBLE-STRAND BREAK REPAIR MUTANTS
    TACCIOLI, GE
    RATHBUN, G
    OLTZ, E
    STAMATO, T
    JEGGO, PA
    ALT, FW
    SCIENCE, 1993, 260 (5105) : 207 - 210
  • [5] V(D)J recombination: Links to transposition and double-strand break repair
    Gellert, M
    Hesse, JE
    Hiom, K
    Melek, M
    Modesti, M
    Paull, TT
    Ramsden, DA
    van Gent, DC
    COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1999, 64 : 161 - 167
  • [6] Role of the Ku autoantigen in V(D)J recombination and double-strand break repair
    Chu, G
    MOLECULAR ANALYSIS OF DNA REARRANGEMENTS IN THE IMMUNE SYSTEM, 1996, 217 : 113 - 132
  • [7] V(D)J recombination RAG recombination centres
    Leavy, Olive
    NATURE REVIEWS IMMUNOLOGY, 2010, 10 (06) : 383 - 383
  • [8] Mechanism of V(D)J recombination
    Zhu, C
    Roth, DB
    CANCER SURVEYS, 1996, 28 : 295 - 309
  • [9] The origins of V(D)J recombination
    Lewis, SM
    Wu, GE
    CELL, 1997, 88 (02) : 159 - 162
  • [10] Biochemistry of V(D)J recombination
    Schatz, DG
    Spanopoulou, E
    MOLECULAR ANALYSIS OF B LYMPHOCYTE DEVELOPMENT AND ACTIVATION, 2005, 290 : 49 - 85
12345