ESTABLISHMENT AND CHARACTERISTICS OF 2 NEW HUMAN MAMMARY-CARCINOMA LINES SERIALLY TRANSPLANTABLE IN NUDE-MICE

被引：12
|
作者：
NAUNDORF, H [1 ]
FICHTNER, I [1 ]
SAUL, GJ [1 ]
HAENSCH, W [1 ]
BUTTNER, B [1 ]
机构：
[1] FREE UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,ROBERT ROSSLE KLIN,W-1000 BERLIN 33,GERMANY
来源：
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1993年 / 119卷 / 11期
关键词：
ESTRADIOL-RECEPTOR-NEGATIVE; C-ERBB2; PROTEIN-POSITIVE; ESTABLISHMENT IN NUDE MICE; HUMAN MAMMARY CARCINOMAS;
D O I：
10.1007/BF01215983
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Two human mammary carcinomas of postmenopausal women were successfully transplanted into nude mice. Both tumours were classified as epidermal-growth-factor-, oestradiol- and progesterone-receptor-negative and c-erbB2-protein-positive. Histological studies of the primary tumours (4000 and 4151) revealed ductal invasive mammary carcinomas. In the first passages the precondition for the growth of breast carcinoma 4000 were pretreatments of the nude mice with oestradiol and peanut oil before transplantation. The mammary carcinomas 4000 and 4151 described here are suitable for in vivo testing of antineoplastic substances and for biological studies.
引用
收藏
页码：652 / 656
页数：5
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