EFFECT OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) ON HUMAN LYMPHOCYTE MATURATION

被引：1
|
作者：
MEHTA, S [1 ]
HOLM, A [1 ]
MEZZANOTTI, T [1 ]
KURL, RN [1 ]
机构：
[1] BROWN UNIV,ROGER WILLIAMS MED CTR,SCH MED,PROGRAM CLIN PHARMACOL,PROVIDENCE,RI 02908
来源：
CHEMOSPHERE | 1992年 / 25卷 / 7-10期
关键词：
D O I：
10.1016/0045-6535(92)90113-6
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The effect of TCDD on lymphocyte activation and proliferation in response to either endogenously produced or exogenously added cellular growth factor(s) was investigated. TCDD effectively reduced proliferation of either freshly prepared or activated T-cells when stimulated with either phytohemagglutinin (PHA-M) and/or recombinant human IL-2 (rIL-2) respectively. Similarly, both freshly activated or preactivated human B-cells with antihuman IgM demonstrated a reduced response to partially purified B-cell growth factor (BCGF) in the presence of TCDD. Also, the synthesis of IL-2 by PHA-M activated T-cells or IgM by PWM stimulated B-cells (in the presence of syngeneic T-cells) was decreased by TCDD. The observed effects of TCDD were concentration dependent and support the conclusion that the xenobiotic is an immunosuppressive agent.
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页码：1095 / 1099
页数：5
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