CENTRAL GABA-A EXCITATORY AND GABA-B INHIBITORY RECEPTORS REGULATE GASTRIC-ACID SECRETION IN RATS

被引：22
|
作者：
DELTACCA, M
BLANDIZZI, C
BERNARDINI, MC
机构：
[1] Laboratory of Molecular Pharmacology, Institute of Pharmacology, University of Pisa, I-56100 Pisa
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 177卷 / 03期
关键词：
(Intracerebroventricular route); (Rat models); Baclofen; Bicuculline; GABA[!sub]A[!/sub] receptors (central); GABA[!sub]B[!/sub] receptors (central); Gastric acid secretion; Muscimol; Phaclofen;
D O I：
10.1016/0014-2999(90)90269-C
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present study investigates the effects of GABAA- and GABAB-receptor agonists and antagonists on gastric secretion after their i.c.v. administration to consious pylorus-ligated rats and anaesthetized stomach lumen-perfused rats. Muscimol was without effect in pylorus-ligated rats, whereas baclofen produced a significant decrease in acid secretion, which was fully prevented by phaclofen. Under these conditions, a significant decrease in acid secretion was also obtained with bicuculline. In stomach lumen-perfused rats, muscimol caused a marked, dose-dependent increase in acid secretion, which was antagonized by bicuculline. Under the same conditions, baclofen induced a moderate, but significant, bicuculline-sensitive increase in acid secretion. Overall, our results suggest the presence of two central GABA pathways which mediate opposite effects: (a) a bicuculline-sensitive GABAA-receptor, the stimulation of which increases acid secretion under pharmacological depression of central vagal tone (anaesthetized rats); (b) a phaclofen-sensitive GABAB-receptor, the activation of which decreases vagally stimulated acid secretion (pylorus-ligated rats). © 1990.
引用
收藏
页码：189 / 194
页数：6
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