HORMONAL EFFECTS, TOLERABILITY, AND PRELIMINARY KINETICS IN MEN OF MK-906, A 5-ALPHA-REDUCTASE INHIBITOR

被引：28

作者：

DESCHEPPER, PJ

IMPERATOMCGINLEY, J

VANHECKEN, A

DELEPELEIRE, I

BUNTINX, A

CARLIN, J

GRESSI, MH

STONER, E

机构：

[1] Department of Pharmacology and Clinical Pharmacology, University of Leuven, School of Medicine, Leuven

[2] Cornell University Medical College, New York, NY

[3] Merck Sharp and Dohme Research Laboratories, Rahway, NJ

来源：

STEROIDS | 1991年 / 56卷 / 09期

关键词：

STEROIDS; 5-ALPHA-REDUCTASE INHIBITOR; PHARMACODYNAMICS; DIHYDROTESTOSTERONE; TESTOSTERONE; HUMAN; PHARMACOKINETICS; FINASTERIDE;

D O I：

10.1016/0039-128X(91)90003-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The hormonal effects following the acute (single dose) administration of a 4-azasteroid inhibitor of 5-alpha-reductase (MK-906) were evaluated in 10 healthy male volunteers. Marked suppression of serum dihydrotestosterone (DHT) was observed after the administration of single doses as low as 12.5 mg. The mean percent decrease in DHT at 24 hours in the group treated with a single 25-mg dose was 56% +/- 10% compared with the baseline. The suppression of plasma DHT levels continued for up to 72 hours. This study demonstrates that administration of single oral doses (12.5 to 400 mg) of MK-906 results in a significant decrease in the conversion of testosterone to DHT.

引用

页码：469 / 471

页数：3

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