BLOCKADE OF CCK-B RECEPTORS BY L-365,260 INDUCES ANALGESIA IN THE SQUIRREL-MONKEY

被引：28
|
作者：
ONEILL, MF
DOURISH, CT
TYE, SJ
IVERSEN, SD
机构：
[1] Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex
来源：
BRAIN RESEARCH | 1990年 / 534卷 / 1-2期
关键词：
Analgesia; Cholecystokinin; Cholecystokinin-B antagonist; L-365,260; Primate; Tail withdrawal test;
D O I：
10.1016/0006-8993(90)90141-W
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The potential antinociceptive effects of the selective cholecystokinin-B (CCK-B) antagonist L-365,260 were examined in the squirrel monkey tail withdrawal test. Pain threshold was measured in 6 male monkeys by recording the latency to remove the tail from a warm (55 °C) water bath. L-365,260 at doses of 100 ng/kg to 100 μg/kg significantly elevated tail withdrawal latencies throughout a 2 h test period. These data provide the first evidence that blockade of CCK-B receptors induces analgesia in primates. © 1990.
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页码：287 / 290
页数：4
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