Potential anticancer agents. XXXVI. Alkylating agents derived from 5-aminouracil

被引：28
|
作者：
Benitez, Allmn
Ross, Leonard O.
Goodman, Leon
Baker, B. R.
机构：
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1960年 / 82卷 / 17期
关键词：
D O I：
10.1021/ja01502a036
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two monofunctional alkylating agents, 5-(2-chloroethylamino)-uracil (V) and 5-12-chloroethyl)-ethylamino]-uracil (VIII), were synthesized for comparison of effectiveness as antitumor compounds with difunctional alkylating agents. An unknown material, obtained via the hydroxyethylation of 5-(ethylamino)-uracil (III), was identified as 3-(2-chloroethvl)-5-[(2-chloroethyl)-ethylaminol-uracil (XIIa) by comparison of its ultraviolet spectra with those of the previously unknown compounds, 5-[bis-(2-chloroethyl)-aminol-3-methyluracil (XVIII) and 5-[bis-(2-cliloroethyl)-amino]-1-methyluracil (XXVI).
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页码：4585 / 4591
页数：7
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