INTERPHASE GENOME AS THE ACTIVE SPACE - CHROMATIN DYNAMICS DURING CHICK-EMBRYO CHONDROGENESIS

被引：12
|
作者：
ERENPREISA, J [1 ]
ZHUKOTSKY, A [1 ]
机构：
[1] MOSCOW PHYSICOCHEM MED RES INST,MOSCOW 119828,RUSSIA
来源：
MECHANISMS OF AGEING AND DEVELOPMENT | 1993年 / 67卷 / 1-2期
关键词：
CYTODIFFERENTIATION; CHROMATIN REARRANGEMENTS; TV IMAGE ANALYSIS;
D O I：
10.1016/0047-6374(93)90109-5
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The rearrangement of the chromatin that takes place during cytodifferentiation was studied using TV image analysis in chick limb bud cartilage stained for DNA. The redistribution of the chromatin was compatible with the Rabl orientation: chromatin was extended radially from the centromeric ring to the telomere pole in young chondroblasts, and contracted back in ageing chondrocytes. The direction and gradient of this redistribution correlate with the changes in DNA content within the chromocentres formed by pericentromeric heterochromatin. In turn, intercalary heterochromatin regulates the condensation of the adjacent euchromatin depending upon the position in this radial-polar gradient.
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页码：21 / 32
页数：12
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