Physiology, pathophysiology and therapeutic implications of enteroendocrine control of food intake

被引:12
|
作者
Elliott, Jessie A. [1 ,2 ,3 ]
Reynolds, John V. [2 ,3 ]
le Roux, Carel W. [1 ,4 ]
Docherty, Neil G. [1 ,4 ]
机构
[1] Univ Coll Dublin, Conway Inst Biomed & Biomol Res, Diabet Complicat Res Ctr, Dublin, Ireland
[2] Trinity Coll Dublin, Trinity Ctr Hlth Sci, Dept Surg, Dublin, Ireland
[3] St James Hosp, Dublin, Ireland
[4] Univ Gothenburg, Sahlgrenska Acad, Gastrosurg Lab, Gothenburg, Sweden
基金
爱尔兰科学基金会;
关键词
Gut hormones; obesity; appetite; hunger; satiety; glucagon-like peptide 1; GLP-1; ghrelin; peptide YY; PYY; oxyntomodulin; OXM; bariatric surgery; body weight; gastric bypass; RYGB; esophagectomy; gastrectomy; malnutrition; weight loss; anorexia; surgery; leptin; insulin; adiponectin; L-cell; hypothalamus;
D O I
10.1080/17446651.2016.1245140
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: With the increasing prevalence of obesity and its associated comorbidities, strides to improve treatment strategies have enhanced our understanding of the function of the gut in the regulation of food intake. The most successful intervention for obesity to date, bariatric surgery effectively manipulates enteroendocrine physiology to enhance satiety and reduce hunger. Areas covered: In the present article, we provide a detailed overview of the physiology of enteroendocrine control of food intake, and discuss its pathophysiologic correlates and therapeutic implications in both obesity and gastrointestinal disease. Expert commentary: Ongoing research in the field of nutrient sensing by L-cells, as well as understanding the role of the microbiome and bile acid signaling may facilitate the development of novel strategies to combat the rising population health threat associated with obesity. Further refinement of post-prandial satiety gut hormone based therapies, including the development of chimeric peptides exploiting the pleiotropic nature of the gut hormone response, and identification of novel methods of delivery may hold the key to optimization of therapeutic modulation of gut hormone physiology in obesity.
引用
收藏
页码:475 / 499
页数:25
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