ONLINE SOLID-PHASE SYNTHESIS OF OLIGONUCLEOTIDE-PEPTIDE HYBRIDS USING SILICA SUPPORTS

被引：56
|
作者：
TRUFFERT, JC
LORTHIOIR, O
ASSELINE, U
THUONG, NT
BRACK, A
机构：
来源：
TETRAHEDRON LETTERS | 1994年 / 35卷 / 15期
关键词：
D O I：
10.1016/0040-4039(94)85218-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A procedure for the preparation of oligonucleotide-peptide hybrid molecules by means of automated synthesis is described. The conjugates have been assembled on silica supports including CPG (Controlled Pore Glass) and Fractosil supports. The novel N-epsilon-lysine protecting group, 1-(3,4-dimethyl-2,6-dioxocyclohex-1-ylidene) ethyl (Dde) was used.
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页码：2353 / 2356
页数：4
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