PRENATAL DEVELOPMENTAL EXPRESSION OF RAT-BRAIN 5-HT(1A) RECEPTOR GENE FOLLOWED BY PCR

被引：43
|
作者：
HILLION, J
MILNEEDWARDS, JBD
CATELON, J
DEVITRY, F
GROS, F
HAMON, M
机构：
[1] CNRS,F-91198 GIF SUR YVETTE,FRANCE
[2] UNIV PARIS 06,INSERM,U288,F-75013 PARIS,FRANCE
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 191卷 / 03期
关键词：
D O I：
10.1006/bbrc.1993.1315
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Expression of the gene encoding the serotonin 5-HT1A receptor was investigated in the brain of rats from embryonic day (ED) 10 to postnatal day 18 using PCR. The 5-HT1A receptor transcripts were first detected as early as ED 12.Their concentration increased to a maximum at ED 15 and decreased progressively to very low levels just before birth (ED 20). In 18-day-old rats, the brain stem levels of 5-HT1A receptor mRNA were higher than at ED 20 but still markedly lower than at ED 15. The high rate of expression of the 5-HT1A receptor gene for a limited period during the fetal life further supports that this receptor might be involved in the trophic action of serotonin during brain maturation. © 1993 Academic Press. All rights reserved.
引用
收藏
页码：991 / 997
页数：7
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