Objectives Describe the correct conservation, storage and elimination of drugs, as well as the legislation regardingmanagement of medicines collected from other patients. Get to know the attitudes and beliefs of professionals in a Health Center regarding medicines collected from patients in the query. Method A bibliographic revision has been made using different data bases (Pubmed, Uptodate, Cochrane library and Fisterra) also Google search engine. And it has been done an observational, descriptive, transversal Study in El Llano's Health Center in order to get to know the management of drugs collected from other patients in Primary Care consultations. Results Medicines must be stowed in places that allow to have optimum conditions of temperature, light, hygiene and security, all this is needed for an adequate conservation. That is why Spanish legislation in force does not allow the use of medicines returned by patients as all of these conditions are not guaranteed. Spanish legislation establishes that is necessary to have controlled strategies to do away with medicines, creating the Integrated System of Management and Collection of packets. The Study shows that 41.4% of professionals do not know the legislative frame for management of medicines collected from patients and that 82.4% states that they have collected, sometimes, medicines at their consultations. Conclusions After the observed results, we consider that it is necessary to spread out the legal aspects related to this topic and to raise awareness in professionals about the conservation of medicines, as it is a key point for the security of patients.