VERMICULIN DERIVATIVES .1. SYNTHESIS OF VERMICULIN DERIVATIVES

被引：0
|
作者：
PROKSA, B
UHRIN, D
ADAMCOVA, J
MUCKOVA, M
FUSKA, J
机构：
[1] TECH UNIV BRATISLAVA, INST CHEM, CS-81237 BRATISLAVA, CZECHOSLOVAKIA
[2] DRUG RES INST, MODRA, CZECHOSLOVAKIA
来源：
PHARMAZIE | 1993年 / 48卷 / 10期
关键词：
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Hydrogenation of the macrodiolide antibiotic vermiculin (1) over Adams catalyst afforded [8S, 16S]-8,16-bis(2'-oxopropyl)-1,9-dioxacyclohexadeca-2,5,10,13-tetrone (2),[8S,16S]-8,16-bis(2'-oxopropyl)-13-hydroxy-1,9-dioxacyclohexadeca-2,5,10-trione (3),[8S,16S]-8,16-bis(2'oxopropyl)-1,9-dioxacyclohexadeca-2,5,10-trione (4) together with [7S]-4,9-dioxo-7-(4',9'-dioxodecanoyloxy) decanoic acid (5). Hydrogenation of diolide 1 over Pd/C gave tetrahydrovermiculin (2) only. The prepared compounds showed lower antibacterial and cytotoxic activities than vermiculin (1).
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页码：738 / 740
页数：3
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