IMMUNOPEROXIDASE STAINING OF HEPATITIS-C VIRUS IN FORMALIN-FIXED, PARAFFIN-EMBEDDED NEEDLE LIVER BIOPSIES

被引：0
|
作者：
UCHIDA, T [1 ]
SHIKATA, T [1 ]
TANAKA, E [1 ]
KIYOSAWA, K [1 ]
机构：
[1] SHINSHU UNIV,SCH MED,DEPT INTERNAL MED,MATSUMOTO,NAGANO 393,JAPAN
来源：
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY | 1994年 / 424卷 / 05期
关键词：
VIRAL HEPATITIS; HEPATITIS VIRUS; HEPATITIS C; HEPATOCELLULAR CARCINOMA; IMMUNOSTAINING;
D O I：
暂无
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The localization of hepatitis C virus (HCV) in the liver has not been well clarified. We report successful indirect immunoperoxidase staining of the HCV core antigen using polyclonal antibodies raised in rabbits and conventional formalin-fixed, paraffin-embedded needle biopsy sections of liver. The core antigen was distributed in a fine granular pattern diffusely, perisinusoidally, or focally within the hepatocellular cytoplasm of livers from patients with HCV infection. The staining tended to show a more heterogeneous pattern in terms of intensity and distribution in cases of more advanced disease. Hepatocellular carcinoma cells were also frequently stained. HCV immunostaining will provide important information on the pathogenesis and treatment of HCV-related liver diseases.
引用
收藏
页码：465 / 469
页数：5
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