LIVER-REGENERATION FOLLOWING PORTACAVAL-SHUNT IN RATS - 3', 5'-CYCLIC AMP CHANGES IN PLASMA AND LIVER-TISSUE

被引：3

作者：

HATA, Y ^{[1
]}

YOSHIKAWA, Y ^{[1
]}

UNE, Y ^{[1
]}

SASAKI, F ^{[1
]}

NAKAJIMA, Y ^{[1
]}

TAKAHASHI, H ^{[1
]}

NAMIENO, T ^{[1
]}

UCHINO, J ^{[1
]}

机构：

[1] HOKKAIDO UNIV,SCH MED,DEPT SURG 1,N-15 W-7,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN

来源：

RESEARCH IN EXPERIMENTAL MEDICINE | 1992年 / 192卷 / 02期

关键词：

LIVER REGENERATION; PORTACAVAL SHUNT; 3'; 5'-CYCLIC AMP;

D O I：

10.1007/BF02576267

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Hepatic regeneration following portacaval shunt was evaluated in the light of the changes of 3', 5'-cyclic AMP (cAMP) levels in plasma and liver tissue, and also plasma cAMP levels after glucagon administration, using a 70% hepatectomy and portacaval shunt model in rats. Ratios of liver to body weight recovered to 60% of pre-operative ratios 2 weeks after the operation. Plasma cAMP level decreased slightly, but insignificantly, 1 day and 3 days after the operation, then recovered to the pre-operative level. Hepatic cAMP concentration increased for 2 weeks after the operation. Plasma cAMP levels induced after glucagon administration did not increase until 3 days after the operation and were only 50% of pre-operative levels 4 weeks after the operation. From these results, liver regeneration following the portacaval shunt was remarkably delayed, but continued until at least 2 weeks after the operation.

引用

页码：131 / 136

页数：6

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