The article presents the results of the empiric study of cognitive and personal factors of emotion regulation, risk of suicide, psychopathologic symptoms and self-injurious behavior. It is hypothesized that the risk of self-destructive behavior is connected to destructive cognitive strategics, dispositional factors of self-injurious and suicidal behavior and psychopathological symptoms. Participants: N=101, aged 13-21. Results: relations between scales of suicidal risk, psychopathological symptoms, self-injurious behavior and cognitive emotional regulation were revealed; differences between groups of instrumental and somatic self-injurers were shown; predictors of self-destructive behavior were defined by linear regression analysis. Summary: somatization, anxiety and psychoticism were related to factors of self-injurious behavior; connections between methods and factors of self-injurious behavior and factors of suicidal risk were discovered; cognitive emotional disregulation (rumination, self-accusation and accusation of others) were predictors of self- destructive behaviors and psychopathological symptoms.