ADDITIVE ENHANCEMENT OF NEUTROPHIL COLLAGENASE ACTIVITY BY HOCL AND CATHEPSIN-G

被引：25
|
作者：
CHATHAM, WW [1 ]
BLACKBURN, WD [1 ]
HECK, LW [1 ]
机构：
[1] DEPT VET AFFAIRS,BIRMINGHAM,AL
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 184卷 / 02期
关键词：
D O I：
10.1016/0006-291X(92)90626-V
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Using preparations of latent collagenase derived from neutrophil specific granule extracts, the relative effects of cathepsin G and HOCl on activation of neutrophil collagenase were determined using a quantitative collagenase assay. Enhancement of collagenase activity by cathepsin G and physiologically relevant concentrations of HOCl were comparable, but HOCl mediated collagenase activation was reversible in the presence of HOCl scavenger. Collagenase activity in preparations treated with cathepsin G and HOCl simultaneously or sequentially was significantly greater than activity in preparations treated with HOCl or cathepsin G alone. The results indicated additive, yet independant enhancing effects of HOCl and cathepsin G on activity of neutrophil collagenase. © 1992.
引用
收藏
页码：560 / 567
页数：8
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