EFFECT OF THE ENHANCEMENT OF THE CHOLINERGIC TONE BY PYRIDOSTIGMINE ON THE EXERCISE-INDUCED GROWTH-HORMONE RELEASE IN MAN

We have evaluated the effect of pyridostigmine (PD), a cholinergic agonist, on the growth hormone (GH) response to physical exercise (EXC) in nine healthy volunteers. PD administration and EXC caused a similar increase of GH secretion to mean (+/-SE) peak values of 5.3+/-0.9 and 6.5+/-1.2 mug/l, respectively. Pretreatment with PD caused a significant augmentation of the EXC-induced GH release evaluated both as maximum peak (13.5+/-2.1 mug/l, p<0.01 vs EXC) and as area under the secretory curve (EXC=292.6+/-41.9 gg.min.1; PD+EXC=587.3+/-68.9 pg.min.1, p<0.005). The action of PD on GH secretion was additive to that of EXC since the sum of the GH responses to PD and EXC was not significantly different from the response obtained during PD+EXC. Whether PD and EXC act through a common final pathway, i.e. inhibition of endogenous somatostatin release, or the EXC-induced GH secretion involves stimulation of endogenous GHRH remains matter of investigation.