Synthesis and Characterisation of Rice Husk Ash Silica Drug Carrier for alpha-Mangostin

被引：4
|
作者：
Iqbal, Anwar [1 ]
Shuib, Nur Azfa Muhammad [2 ]
Darnis, Deny Susanti [2 ]
Miskam, Mazidatulakmam [1 ]
Rahman, Nur Ruzaina Abdul [1 ]
Adam, Farook [1 ]
机构：
[1] Univ Sains Malaysia, Sch Chem Sci, Usm Pulau Pinang 11800, Malaysia
[2] Int Islamic Univ Malaysia, Kulliyyah Sci, Dept Chem, Kuantan Campus, Kuantan 25200, Pahang, Malaysia
来源：
JOURNAL OF PHYSICAL SCIENCE | 2018年 / 29卷 / 03期
关键词：
Rice husk; silica; sol-gel; drug carrier; alpha-mangostin;
D O I：
10.21315/jps2018.29.3.8
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The potential of rice husk ash (RHA) silica prepared via sol-gel method (RHA-Si) as a drug carrier was investigated. The nitrogen adsorption-desorption isotherm of RHA-Si indicates the presence of mesopores and some small percentage of micropores. The Brunauer, Emmett and Teller (BET) surface area of RHA-Si was 589 m(2) g(-1) and the Barrett-Joyner-Halenda (BJH) pore size was 5.1 nm. The adsorption of alpha-mangostin was confirmed by Fourier transform infrared (FTIR) spectroscopy and thermogravimetric analysis (TGA). The sample containing alpha-mangostin was labeled as RHA-Si-alpha. The BET surface area of RHA-Si-alpha was 110 m(2) g(-1) with the BJH pore size of 24.4 nm. The X-ray powder diffraction (XRD) showed that the RHA-Si and RHA-Si-alpha were amorphous. The disappearance of crystallinity of alpha-mangostin indicates that the solubility and dissolution of alpha-mangostin have been improved. The drug release profile indicated a burst release corresponding to 47% of the total drug loading in the first 15 min. The burst release was caused by physically adsorbed drug molecules. The findings suggest that RHA silica has potential application as nano drug carrier.
引用
收藏
页码：95 / 107
页数：13
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