AN ETHER-BASED PEPTIDE ANALOG AS CAMP-DEPENDENT PROTEIN-KINASE INHIBITOR/SUBSTRATE

被引：3
|
作者：
HO, MF
UHRIN, A
HUANG, M
机构：
[1] Department of Medicinal Chemistry, School of Pharmacy, State University of New York at Buffalo, Buffalo
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 04期
关键词：
D O I：
10.1016/S0960-894X(01)80153-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Ether-based peptide analog L-EP contains an ether-linkage unit in place of the Ser-Leu-Gly unit of a PKA substrate, kemptide. L_EP is a competitive inhibitor of kemptide phosphorylation catalyzed by PKA with a K-i value of 120 mu M. It also serves as a weak substrate of PKA with a K-m value 25-fold higher and a V-max value 3.5-fold lower than that of Kemptide.
引用
收藏
页码：553 / 556
页数：4
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