MECHANICAL HYPERALGESIA IN STREPTOZOTOCIN-DIABETIC RATS IS NOT SYMPATHETICALLY MAINTAINED

被引：22
|
作者：
AHLGREN, SC
LEVINE, JD
机构：
[1] UNIV CALIF SAN FRANCISCO,DEPT ANAT,BOX 0452A,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143
[3] UNIV CALIF SAN FRANCISCO,DEPT ORAL & MAXILLOFACIAL SURG,SAN FRANCISCO,CA 94143
[4] UNIV CALIF SAN FRANCISCO,GRAD PROGRAM BIOMED SCI,SAN FRANCISCO,CA 94143
[5] UNIV CALIF SAN FRANCISCO,PROGRAM NEUROSCI,SAN FRANCISCO,CA 94143
来源：
BRAIN RESEARCH | 1993年 / 616卷 / 1-2期
关键词：
STREPTOZOTOCIN-INDUCED DIABETES; RAT; PERIPHERAL NEUROPATHY; SYMPATHETICALLY MAINTAINED PAIN; NOREPINEPHRINE; MECHANICAL NOCICEPTIVE THRESHOLD;
D O I：
10.1016/0006-8993(93)90206-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
It has been suggested that the mechanism underlying the pain that occurs in patients with diabetic neuropathy may be similar to that mediating sympathetically maintained pain (SMP), such as occurs in patients with reflex sympathetic dystrophy. To evaluate this suggestion we have examined a model of diabetes mellitus, the streptozotocin-diabetic (STZ-D) rat, for features characteristic of SMP. We demonstrate that the decrease in nociceptive threshold observed in the STZ-D rat is not attenuated by chemical sympathectomy nor exacerbated by intradermal injection of norepinephrine (NE). In addition, the NE content is markedly decreased in the skin of the STZ-D rat. These results suggest that altered nociceptive thresholds associated with diabetic neuropathy are not sympathetically maintained.
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页码：171 / 175
页数：5
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