Nuclease Composition with Anti-Rabies Activity

被引：0

作者：

Khismatullina, Nailya ^{[1
]}

Ivanov, Arkadiy ^{[1
]}

Martynova, Ekaterina ^{[2
]}

Mironov, Alexander ^{[1
]}

Zainutdinova, Elmira ^{[2
]}

Khaiboullina, Svetlana ^{[2
]}

Rizvanov, Albert ^{[2
]}

Filimonova, Maria ^{[2
]}

机构：

[1] Fed Ctr Toxicol Radiat & Biol Safety, Kazan 420075, Tatarstan, Russia

[2] Kazan Fed Univ, Inst Fundamental Med & Biol, Kremliovskaya St 18, Kazan 420008, Tatarstan, Russia

来源：

JOURNAL OF PURE AND APPLIED MICROBIOLOGY | 2014年 / 8卷

关键词：

Nuclease; Serratia marcescens; Sma nuc; Rabies; Postexposure protection;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A composition demonstrating anti-rabies activity was developed on the basis of isoform Sm1 of Serratia marcescens endonuclease. Besides the enzyme the composition contained Haemodes-N, magnesium sulfate and sodium chloride. Injection of this composition at a mouse's infection cite, two hours after the mouse has been infected with rabies, showed an increase of the infected animals' survival by more than 30% in comparison with the animals of control group.

引用

页码：499 / 504

页数：6

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