2ND MESSENGERS INVOLVED IN THE REGULATION OF CORTICOTROPIN-RELEASING HORMONE MESSENGER-RNA AND PEPTIDE IN CULTURED RAT FETAL HYPOTHALAMIC PRIMARY CULTURES

被引：67
|
作者：
EMANUEL, RL
GIRARD, DM
THULL, DL
MAJZOUB, JA
机构：
[1] Division of Endocrinology, Department of Medicine, Children’s Hospital, Harvard Medical School, Boston, MA
来源：
ENDOCRINOLOGY | 1990年 / 126卷 / 06期
关键词：
D O I：
10.1210/endo-126-6-3016
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Using primary cultures of dispersed rat fetal hypothalami, we studied the effect of forskolin and the phorbol ester 12-o-tetradecanoyl phorbol 13-acetate, activators of protein kinase A and C, respectively, on corticotropin-releasing hormone (CRH) regulation. CRH mRNA accumulation and peptide release were stimulated by both agents, indicating that the protein kinase A and protein kinase C messenger systems are involved in the regulation of CRH gene expression and are functional in hypothalamic neurons isolated from fetal brain. © 1990 by The Endocrine Society.
引用
收藏
页码：3016 / 3021
页数：6
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