ELECTROCHROMATOGRAPHIC SOLID-PHASE EXTRACTION FOR DETERMINATION OF CIMETIDINE IN SERUM BY MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY

被引：45

作者：

SOINI, H ^{[1
]}

TSUDA, T ^{[1
]}

NOVOTNY, MV ^{[1
]}

机构：

[1] INDIANA UNIV,DEPT CHEM,BLOOMINGTON,IN 47405

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 559卷 / 1-2期

关键词：

D O I：

10.1016/0021-9673(91)80102-M

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A highly effective electrochromatographic solid-phase extraction and preconcentration method is reported for the determination of cimetidine in serum in the concentration range 0.233-11.4-mu-g/ml. Preconcentrated samples were determined by micellar electrokinetic capillary chromatography while ranitidine was used as an internal standard. Sample preparation included retention of the analyte on a C18 solid-phase cartridge, followed by elution assisted by an applied voltage of 150 V. From 0.5-ml serum samples, 20-50-mu-l aliquots were collected for electrophoretic analysis. Within the studied concentration range, the method was linear and provided adequate precision.

引用

页码：547 / 558

页数：12

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