EFFECTS OF DNA-BINDING DRUGS ON T4 DNA-LIGASE

被引：16
|
作者：
MONTECUCCO, A
PEDRALINOY, G
SPADARI, S
LESTINGI, M
CIARROCCHI, G
机构：
来源：
BIOCHEMICAL JOURNAL | 1990年 / 266卷 / 02期
关键词：
D O I：
10.1042/bj2660379
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A number of DNA intercalating and externally binding drugs have been found to inhibit nick sealing, cohesive and blunt end ligation, AMP-dependent DNA topoisomerization and EDTA-induced DNA nicking mediated by bacteriophage T4 DNA ligase. The inhibition seems to arise from drug-substrate interaction so that formation of active DNA-Mg2+-AMP-enzyme complex is impaired while assembled and active complexes are not disturbed by drug binding to the substrate.
引用
收藏
页码：379 / 384
页数：6
相关论文
共 50 条
  • [1] SEALING OF GAPS IN DUPLEX DNA BY T4 DNA-LIGASE
    NILSSON, SV
    MAGNUSSON, G
    [J]. NUCLEIC ACIDS RESEARCH, 1982, 10 (05) : 1425 - 1437
  • [2] DNA UNWINDING AND INHIBITION OF T4 DNA-LIGASE BY ANTHRACYCLINES
    MONTECUCCO, A
    PEDRALINOY, G
    SPADARI, S
    ZANOLIN, E
    CIARROCCHI, G
    [J]. NUCLEIC ACIDS RESEARCH, 1988, 16 (09) : 3907 - 3918
  • [3] A NOVEL DNA JOINING ACTIVITY CATALYZED BY T4 DNA-LIGASE
    WESTERN, LM
    ROSE, SJ
    [J]. NUCLEIC ACIDS RESEARCH, 1991, 19 (04) : 809 - 813
  • [4] PURIFICATION OF THE T4 DNA-LIGASE BY BLUE SEPHAROSE CHROMATOGRAPHY
    SUGIURA, M
    [J]. ANALYTICAL BIOCHEMISTRY, 1980, 108 (02) : 227 - 229
  • [5] TREATMENT OF GENOMIC DNA WITH T4 DNA-LIGASE IMPROVES SOUTHERN BLOT ANALYSIS
    KOCH, JE
    KOLVRAA, S
    CORNELIUSEN, M
    PETERSEN, KB
    GREGERSEN, N
    BOLUND, LA
    [J]. NUCLEIC ACIDS RESEARCH, 1988, 16 (21) : 10387 - 10387
  • [6] COMPARATIVE-ANALYSIS OF T6 AND T4 DNA-LIGASE GENES
    KALIMAN, AV
    ZIMIN, AA
    NAZIPOVA, NN
    KRIUKOV, VM
    TANIASHIN, VI
    KRAEV, AS
    MIRONOVA, MV
    SKRIABIN, KG
    BAYEV, AA
    [J]. DOKLADY AKADEMII NAUK SSSR, 1988, 299 (03): : 737 - 742
  • [7] INDUCTION OF T4 DNA-LIGASE IN A RECOMBINANT STRAIN OF ESCHERICHIA-COLI
    WHITNEY, GK
    GLICK, BR
    ROBINSON, CW
    [J]. BIOTECHNOLOGY AND BIOENGINEERING, 1989, 33 (08) : 991 - 998
  • [8] LIGATION OF RESTRICTION ENDONUCLEASE-GENERATED DNA FRAGMENTS USING IMMOBILIZED T4 DNA-LIGASE
    BULOW, L
    MOSBACH, K
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1982, 107 (02) : 458 - 464
  • [9] RAPID PURIFICATION OF T4 DNA-LIGASE FROM A LAMBDA-T4 LIG LYSOGEN
    TAIT, RC
    RODRIGUEZ, RL
    WEST, RW
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1980, 255 (03) : 813 - 815
  • [10] REPAIR OF POTENTIALLY LETHAL DAMAGE BY INTRODUCTION OF T4 DNA-LIGASE IN EUKARYOTIC CELLS
    DURANTE, M
    GROSSI, GF
    NAPOLITANO, M
    GIALANELLA, G
    [J]. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1991, 59 (04) : 963 - 971
12345