ISOTHIOCYANATES INHIBIT CELL-CYCLE PROGRESSION OF HELA-CELLS AT G2/M PHASE

被引：69
|
作者：
HASEGAWA, T
NISHINO, H
IWASHIMA, A
机构：
[1] Department of Biochemistry, Kyoto Prefectural Univ. of Medicine, Kamigyo-ku
来源：
ANTI-CANCER DRUGS | 1993年 / 4卷 / 02期
关键词：
G2/M PHASE ARREST; GROWTH INHIBITORY EFFECT; ISOTHIOCYANATE;
D O I：
10.1097/00001813-199304000-00021
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To analyze the inhibitory effects of isothiocyanates on the growth of human cancer cells, the effects of these compounds on the cell cycle progression of HeLa cells were studied by flow cytometry. The accumulation of cells at G2/M phase was observed at 16 h after treatment with 10 muM allyl isothiocyanate, 2.5 muM benzyl or phenethyl isothiocyanate, at which concentrations the cell growth was inhibited to 41-79% of control. These results suggest that isothiocyanates delay the cell cycle progression of HeLa cells, leading to inhibition of cell growth.
引用
收藏
页码：273 / 279
页数：7
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