This review provides an overview of latest insights in epithelial ovarian cancer biology. The current understanding of the origin and the complex heterogeneity are depicted, followed by an introduction to the latest therapeutic approaches. The role of the tumor microenvironment, the high potential to disseminate within the peritoneal cavity, and new molecular biological findings are summarized.
机构:
Department of Obstetrics and Gynecology, Molecular Oncology Group, Comprehensive Cancer Center, Medical University of Vienna, Währinger Gürtel 18–20, ViennaDepartment of Obstetrics and Gynecology, Molecular Oncology Group, Comprehensive Cancer Center, Medical University of Vienna, Währinger Gürtel 18–20, Vienna
Aust S.
Pils D.
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机构:
Department of Obstetrics and Gynecology, Molecular Oncology Group, Comprehensive Cancer Center, Medical University of Vienna, Währinger Gürtel 18–20, ViennaDepartment of Obstetrics and Gynecology, Molecular Oncology Group, Comprehensive Cancer Center, Medical University of Vienna, Währinger Gürtel 18–20, Vienna
机构:
Radboud Univ Nijmegen, Med Ctr, Dept Med Oncol 452, PO 9101, NL-6500 HB Nijmegen, NetherlandsRadboud Univ Nijmegen, Med Ctr, Dept Med Oncol 452, PO 9101, NL-6500 HB Nijmegen, Netherlands
机构:
Univ Calif San Francisco, Ctr Comprehens Canc, Dept Urol, San Francisco, CA 94143 USAUniv Calif San Francisco, Ctr Comprehens Canc, Dept Urol, San Francisco, CA 94143 USA
Dall'Era, Marc
Carroll, Peter R.
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Univ Calif San Francisco, Ctr Comprehens Canc, Dept Urol, San Francisco, CA 94143 USAUniv Calif San Francisco, Ctr Comprehens Canc, Dept Urol, San Francisco, CA 94143 USA
机构:
Univ Pittsburgh, Div Infect Dis, Sch Med, Pittsburgh, PA USAUniv Pittsburgh, Div Infect Dis, Sch Med, Pittsburgh, PA USA
Sigler, Rachel
Haidar, Ghady
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Univ Pittsburgh, Div Infect Dis, Sch Med, Pittsburgh, PA USA
Univ Pittsburgh, Div Infect Dis, 3601 Fifth Ave, Falk Med Bldg, Suite 5B, Pittsburgh, PA 15213 USAUniv Pittsburgh, Div Infect Dis, Sch Med, Pittsburgh, PA USA