GLOBAL AND LOCAL METRIC GEOMETRY OF LIGAND-BINDING THERMODYNAMICS

被引：6
|
作者：
DICERA, E [1 ]
WYMAN, J [1 ]
机构：
[1] UNIV COLORADO,DEPT CHEM & BIOCHEM,BOULDER,CO 80309
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 08期
关键词：
LINKAGE; EQUILIBRIUM; MACROMOLECULE;
D O I：
10.1073/pnas.88.8.3494
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
An abstract metric representation of ligand binding thermodynamics reveals the basic connections between the classical thermodynamic theory of binding and linkage [Wyman, J. (1964) Adv. Protein Chem. 19, 223-286] and its site-specific formulation [Di Cera, E. (1990) Biophys. Chem. 37, 147-164]. These two approaches are limit cases of a general metric formulation of binding and linkage that also includes a number of intermediate "mixed" representations.
引用
收藏
页码：3494 / 3497
页数：4
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