Myelodysplastic syndroms: epidemiology, diagnosis and treatment

被引：0
|
作者：
Roux, Clemence [1 ,2 ,3 ]
Roulin, Louise [4 ]
机构：
[1] Hop Archet, Ctr Hosp Univ Nice, Serv Hematol Clin, F-06202 Nice 03, France
[2] CNRS, UMR 7370, LP2M, Fac Med, 28 Ave Valombrose, F-06107 Nice 2, France
[3] Univ Nice Sophia Antipolis, Parc Valrose, Nice, France
[4] Univ Paris Diderot, Hop St Louis 1, Inst Univ Hematol, Inserm,U944,CNRS,UMR 7212, 1 Ave Claude Vellefaux, F-75010 Paris, France
来源：
HEMATOLOGIE | 2016年 / 22卷 / 04期
关键词：
myelodysplastic syndroms; therapeutic advancements; pathophysiology;
D O I：
10.1684/hma.2016.1171
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Myelodysplastic syndroms are heterogeneous myeloid disorders caracterized by cytopenias associated with an ineffectiv hematopoiesis and a variable pourcentage of blasts. These are hematologic diseases that frequently affect older adults. The main risk of MDS is evolution into acute myeloid leukemia. Recent advancements in flow cytometry and molecular biology are henceforth useful to better define prognosis and therapeutic decision. During the last ten years, new therapeutic findings (identification of potential cellular and molecular targets) and reduced-intensity conditioning therapy in allogeneic stem cell transplantation improved the prognosis of patients with myelodysplastic syndroms.
引用
收藏
页码：288 / 296
页数：9
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