IGG4 AUTOANTIBODIES TO DNA IN SYSTEMIC LUPUS-ERYTHEMATOSUS PATIENTS

被引：2
|
作者：
NAGPAL, S
NAMBOODIRI, MSA
RAO, BSS
RAO, PVS
机构：
[1] INDIAN INST SCI,DEPT BIOCHEM,IMMUNOL & ALLERG DIS LAB,BANGALORE 560012,KARNATAKA,INDIA
[2] INDIAN INST SCI,CTR HLTH,BANGALORE 560012,KARNATAKA,INDIA
来源：
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1991年 / 95卷 / 01期
关键词：
D O I：
10.1159/000235445
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
The presence of DNA-specific IgG4 antibodies was demonstrated in the sera of patients with systemic lupus erythematosus (SLE) by a microtiter solid-phase radioimmunoassay. A patient with distal interphalangeal swelling and extensive ulcers in the oral cavity, seronegative for anti-DNA antibodies of the IgG isotype, was found to have anti-DNA autoantibodies exclusively of the IgG4 subclass. These autoantibodies directed against the dsDNA conformation cross-reacted with chondroitin sulfate, dermatan sulfate and heparin.
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页码：1 / 6
页数：6
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