ENANTIOSELECTIVE INHIBITION OF HUMAN-LEUKOCYTE ELASTASE

被引：10
|
作者：
GROUTAS, WC
BRUBAKER, MJ
VENKATARAMAN, R
STANGA, MA
机构：
[1] Department of Chemistry, Wichita State University, Wichita
来源：
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1992年 / 297卷 / 01期
关键词：
D O I：
10.1016/0003-9861(92)90652-D
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
(RS)-Diethyl-2-benzylsuccinate was resolved using α-chymotrypsin. The two enantiomers were then elaborated to yield (S)-(+) and (R)-(-)-3-benzyl-N-[(methylsulfonyl)oxy] succinimide and the inhibitory activity of the two enantiomers toward human leukocyte elastase was subsequently determined. The k2 KI values for the R and S isomers were found to be 330 and 1500 m-1 s-1, respectively. © 1992.
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收藏
页码：144 / 146
页数：3
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