SYMPTOMS OF DENGUE FEVER IN RELATION TO HOST IMMUNOLOGICAL RESPONSE AND VIRUS SEROTYPE, PUERTO-RICO, 1990-1991

被引:46
|
作者
COBRA, C
RIGAUPEREZ, JG
KUNO, G
VORNDAM, V
机构
[1] JOHNS HOPKINS UNIV, SCH HYG & PUBL HLTH, DEPT INT HLTH, BALTIMORE, MD USA
[2] CTR DIS CONTROL & PREVENT, NATL CTR INFECT DIS, DIV VECTOR BORNE INFECT DIS, DENGUE BRANCH, SAN JUAN, PR USA
[3] CTR DIS CONTROL & PREVENT, NATL CTR INFECT DIS, DIV VECTOR BORNE INFECT DIS, FT COLLINS, CO 80522 USA
关键词
ARBOVIRUS INFECTIONS; DENGUE; DENGUE VIRUS; HEMORRHAGIC FEVERS; VIRAL; IMMUNOLOGICAL SURVEILLANCE;
D O I
10.1093/oxfordjournals.aje.a117579
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The authors investigated the role of secondary immunologic response, virus serotype, age, and sex on the clinical manifestations of dengue fever in Puerto Rico. From surveillance data for 1990 and 1991, this study identified 3,926 laboratory-positive cases, including 889 for whom dengue immunologic status and symptoms could be ascertained. Of those, 622 cases were virologically confirmed, and 267 cases were serologically confirmed. More than 50% of all positive patients reported fever, chills, headache, eye pain, body pains, joint pains, nausea, vomiting, or skin rash. The frequency of reporting signs, symptoms, and hospitalization was significantly higher among persons with secondary infections diagnosed by serologic methods, Only rash was more common among those with primary infections, Symptom reporting increased with age; body pains, joint pains, and rash were significantly more frequently reported by female patients. No significant difference in symptom frequency was found among the virologically confirmed cases, comparing primary and secondary cases or infections due to different serotypes, The data for serologically confirmed cases suggest that in Puerto Rico the manifestations of dengue fever are, as with dengue hemorrhagic fever in Asia, more prominent among those who are experiencing secondary infections, and this effect may be more marked in the younger age groups.
引用
收藏
页码:1204 / 1211
页数:8
相关论文
共 2 条
  • [1] DENGUE FEVER SYMPTOMS IN RELATION TO SECONDARY IMMUNOLOGICAL RESPONSE IN PUERTO-RICO, 1990-1991
    COBRA, C
    RIGAUPEREZ, JG
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1993, 138 (08) : 648 - 648
  • [2] AEDES-AEGYPTI IN PUERTO-RICO - ENVIRONMENTAL DETERMINANTS OF LARVAL ABUNDANCE AND RELATION TO DENGUE VIRUS TRANSMISSION
    MOORE, CG
    CLINE, BL
    RUIZTIBEN, E
    LEE, D
    ROMNEYJOSEPH, H
    RIVERACORREA, E
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1978, 27 (06): : 1225 - 1231