PROPOFOL DECREASES RANDOM AND CHEMOTACTIC STIMULATED LOCOMOTION OF HUMAN NEUTROPHILS INVITRO

被引：35
|
作者：
JENSEN, AG [1 ]
DAHLGREN, C [1 ]
EINTREI, C [1 ]
机构：
[1] GOTHENBURG UNIV,DEPT MED MICROBIOL & IMMUNOL,S-41346 GOTHENBURG,SWEDEN
来源：
BRITISH JOURNAL OF ANAESTHESIA | 1993年 / 70卷 / 01期
关键词：
ANESTHETICS; INTRAVENOUS; PROPOFOL; BLOOD; LEUKOCYTES; TOXICITY; LEUKOCYTE CHEMOTAXIS;
D O I：
10.1093/bja/70.1.99
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
We have studied the influence of clinical concentrations of propofol (2,6-diisopropyl phenol), emulsified propofol (Diprivan) and the emulsifier of propofol (Intralipid 10%) on random and chemotactic locomotion of human polymorphonuclear leucocytes in an agarose assay. Random locomotion was decreased (P < 0.001) to a similar extent by the three drugs. Concentrations of propofol 2.5 mug ml-1 and greater, and of Diprivan 3.33 mug ml-1 and greater, also reduced chemotaxis (P < 0.05) against both zymosan-activated human serum (C5a) and N-formyl-methionyl-leucyl-phenylalanine (FMLP), used as chemoattractants. Intralipid reduced chemotaxis towards C5a but not towards FMLP. We conclude that propofol in clinically relevant concentrations may adversely affect leucocyte locomotion in vitro.
引用
收藏
页码：99 / 100
页数：2
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